Research

AGP for clinical trials:

Currently the IDC uses a SAS® program for producing research AGPs. The research AGP includes a second row of statistics: Glucose Variability, Exposure and Episodes close ups.

Our systems are able to produce CGM and SMBG reports. We can produce batched reports for different time periods, demographic sub populations and intervention arms. IDC provides AGP interpretation as well as research analytic reporting. If you want us to produce AGPs for your next research trial; we would be glad to help.

Research Intake Form

Common statistics we produce include: Episodes close up, Avg. Min. per Day, Mean Episodes/Day, Mean Duration (Min.), AUC Hourly including glucose exposures by period [Wake: between 6am and midnight; Sleep: between midnight and 6am; 24 Hours: from midnight to midnight], IQR (interquartile range), MAGE (Mean Amplitude of Glycemic Excursion), MODD (Mean of Daily Differences), LGBI (Low Blood Glucose Index), and HBGI (High Blood Glucose Index).

"It is an efficient tool in standardizing CGM and SMBG data" -Clinician

"AGP is clean- across platforms!!" -Clinician


Where you can next meet our team:

ADA Annual Scientific Meeting in New Orleans, LA June 3-7, 2022


References

  1. Bergenstal RM, Beck RW, Close KL, Grunberger G, Sacks DB, Kowalski A, Brown AS, Heinemann L, Aleppo G, Ryan DB, Riddlesworth TD, and Cefalu WT. (2018) Diabetes Care, 41:2275-2280

  2. Bergenstal RM. (2018). Continuous glucose monitoring: transforming diabetes management step by step. Lancet , 391(10128):1334-1336.

  3. Riddlesworth TD, Beck RW, Gal RL, Connor CG, Bergenstal RM, Lee S, Willi SM. (2018) Optimal Sampling Duration for Continuous Glucose Monitoring to Determine Long-Term Glycemic Control. Diabetes Technol Ther. , 20(4):314-316.

  4. Mullen DM, Bergenstal R, Criego A, Arnold KC, Goland R, Richter S. (2018) Time Savings Using a Standardized Glucose Reporting System and Ambulatory Glucose Profile. J Diabetes Sci Technol., 12(3):614-621.

  5. Danne T, Nimri R, Battelino T, Bergenstal RM, Close KL , DeVries HJ, ... & Beck R. (2017). International consensus on use of continuous glucose monitoring. Diabetes Care, 40(12), 1631-1640.

  6. Riddle MC, Gerstein HC, and Cefalu WT. (2017). "Maturation of CGM and Glycemic Measurements Beyond HbA1c—A Turning Point in Research and Clinical Decisions." Diabetes Care, 40(12), 1611-1613.

  7. Petrie JR, Peters AL, Bergenstal RM, Holl RW., Fleming GA., & Heinemann L. (2017). Improving the clinical value and utility of CGM systems: issues and recommendations. Diabetologia, 60(12), 2319-2328.

  8. Buckingham BA, Close KL, Bergenstal RM, Danne T, Grunberger G, Kowalski AJ, Peters A, Heller SR (2017). Reaching an International Consensus on Standardizing Continuous Glucose Monitoring (CGM) Outcomes―Aligning Clinicians, Researchers, Patients, and Regulators. American Diabetes Association 77th Scientific Meeting, San Diego, CA.

  9. Carlson AL, Mullen DM, & Bergenstal RM. (2017). Clinical use of continuous glucose monitoring in adults with type 2 diabetes. Diabetes Technology & Therapeutics, 19(S2), S-4.

  10. Mullen DM, et al. (2015). Reduced Staff Time with Optimized Work Flows and Standardized Ambulatory Glucose Profile (AGP) American Diabetes Association Scientific Meeting. Boston, MA.

  11. Mullen, DM, et al. (2015). Understanding patient and clinician glucose reporting preferences in type 1 diabetes: Ambulatory Glucose Profile (AGP). Diabetologia, Springer, New York, NY.

  12. Mullen, DM, et al. (2015). Understanding Patient and Clinician Glucose Reporting Preferences in Type 1 Diabetes: Ambulatory Glucose Profile (AGP) European Association for the Study of Diabetes Annual Meeting. Stockholm, Sweden.

  13. Bergenstal RM, et al. (2013). "Recommendations for standardizing glucose reporting and analysis to optimize clinical decision making in diabetes: the Ambulatory Glucose Profile (AGP)." Diabetes technology & therapeutics, 15(3): 198-211.

  14. Matthaei S. (2014). "Assessing the value of the Ambulatory Glucose Profile in clinical practice." British Journal of Diabetes, 14(4): 148-152.

  15. Matthaei,S., et al. (2014). "Consensus recommendations for the use of Ambulatory Glucose Profile in clinical practice." British Journal of Diabetes, 14(4): 153-157.

  16. Mazze RS, et al. (2008). "Characterizing glucose exposure for individuals with normal glucose tolerance using continuous glucose monitoring and ambulatory glucose profile analysis." Diabetes technology & therapeutics, 10(3): 149-159.

  17. Mazze RS, et al. (1987). "Ambulatory glucose profile: representation of verified self-monitored blood glucose data." Diabetes Care, 10(1): 111-117.